Antioxidants in Huntington's disease

Applying Bioinfomatics Strategies in Huntingtons Disease Research

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

Huntingtin and the molecular pathogenesis of Huntingtons disease

Huntington’s disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt). The normal function of htt, and the molecular mechanisms that contribute to the disease pathogenesis, are in the process of being elucidated. In this review...

Antioxidants in health and disease.

Research on antioxidants proceeds at full speed after a partial decline of public interest, when claims on effectiveness of mega doses of vitamin C proved unfounded. The main role of antioxidants is to liquidate the uncontrolled production of reactive oxygen species (ROS) that is being linked to pathogenesis of cardiovascular disease (CVD), malignancy, diabetes type 2, mechanism of infection, f...

Natural antioxidants in Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by severe cognitive impairment that ultimately leads to death. Current drugs used in AD are acetylcholinesterase inhibitors and antagonists to the NMDA receptors. These drugs may only slightly improve cognitive functions but have only very limited impact on the clinical course of the disease. In the past several ...